The natural olive constituent oleuropein induces nutritional cardioprotection in normal and cholesterol-fed rabbits: comparison with preconditioning.

  title={The natural olive constituent oleuropein induces nutritional cardioprotection in normal and cholesterol-fed rabbits: comparison with preconditioning.},
  author={Ioanna Andreadou and Dimitra Benaki and Panagiotis Efentakis and Sofia-Iris Bibli and A. Milioni and Anastasia Papachristodoulou and Anastasia Zoga and Alexios-Leandros Skaltsounis and Emmanuel Mikros and Efstathios K. Iliodromitis},
  journal={Planta medica},
  volume={81 8},
Ischemic preconditioning, which is mediated by cell signaling molecules, protects the heart from ischemia-reperfusion injury by limiting the infarct size. Oleuropein, the main polyphenolic constituent of olives, reduced the infarct size in normal and cholesterol-fed rabbits when it was administered at a nutritional dose. The aim of the present study was to compare the effects of oleuropein and preconditioning in terms of the cell signaling and metabolism pathways underlying myocardial… 

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