The natural killer complex regulates severe malarial pathogenesis and influences acquired immune responses to Plasmodium berghei ANKA.

@article{Hansen2005TheNK,
  title={The natural killer complex regulates severe malarial pathogenesis and influences acquired immune responses to Plasmodium berghei ANKA.},
  author={Diana Silvia Hansen and Krystal J. Evans and Marthe C. D'Ombrain and Nicholas J. Bernard and Adrienne C. Sexton and Lynn A Buckingham and Anthony A. Scalzo and Louis Schofield},
  journal={Infection and immunity},
  year={2005},
  volume={73 4},
  pages={2288-97}
}
The natural killer complex (NKC) is a genetic region of highly linked genes encoding several receptors involved in the control of NK cell function. The NKC is highly polymorphic, and allelic variability of various NKC loci has been demonstrated in inbred mice. Making use of BALB.B6-Cmv1r congenic mice, in which the NKC from disease-susceptible C57BL/6 mice has been introduced into the disease-resistant BALB/c background, we show here that during murine malaria infection, the NKC regulates a… CONTINUE READING

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