The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells.

@article{Bertozzi2014TheNI,
  title={The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells.},
  author={Davide Bertozzi and Jessica Marinello and Stefano Giustino Manzo and Francesca Fornari and Laura Gramantieri and Giovanni Capranico},
  journal={Molecular cancer therapeutics},
  year={2014},
  volume={13 1},
  pages={
          239-48
        }
}
DNA topoisomerase I (Top1) inhibition by camptothecin derivatives can impair the hypoxia-induced cell transcriptional response. In the present work, we determined molecular aspects of the mechanism of camptothecin's effects on hypoxia-inducible factor-1α (HIF-1α) activity in human cancer cells. In particular, we provide evidence that low concentrations of camptothecin, without interfering with HIF-1α mRNA levels, can reduce HIF-1α protein expression and activity. As luciferase assays… CONTINUE READING
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