The natural history of transfer RNA and its interactions with the ribosome

@inproceedings{CaetanoAnolls2014TheNH,
  title={The natural history of transfer RNA and its interactions with the ribosome},
  author={Gustavo Caetano-Anoll{\'e}s and Feng-Jie Sun},
  booktitle={Front. Genet.},
  year={2014}
}
Transfer RNA (tRNA) is undoubtedly the most central and one of the oldest molecules of the cell. Without it genetics and coded protein synthesis are impossible. The crucial specificities responsible for the genetic code and accurate translation are by far entrusted to interactions between tRNA and translation proteins, fundamentally aminoacyl-tRNA synthetase (aaRS) enzymes and elongation factor (EF) switches (Yadavalli and Ibba, 2012). Discrimination mediated by aaRSs and EFs against… CONTINUE READING
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