The natural history of tolerance to the benzodiazepines.

@article{Higgitt1988TheNH,
  title={The natural history of tolerance to the benzodiazepines.},
  author={Anna Higgitt and Peter Fonagy and M. H. Lader},
  journal={Psychological medicine. Monograph supplement},
  year={1988},
  volume={13},
  pages={
          1-55
        }
}
Dependence on benzodiazepines following continued use is by now a well-documented clinical phenomenon. Benzodiazepines differ in their dependence potential. The present studies were aimed at examining the possibility that differential rates of tolerance development might account for differences in dependence risk. Four studies are reported. The first three studies concerned normal subjects. The development of tolerance over a fifteen day period was demonstrated for three different… 

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