The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study.

@article{RangelFrausto1995TheNH,
  title={The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study.},
  author={Manuel Sigfrido Rangel-Frausto and Didier Pittet and M D Costigan and T Hwang and Charles S. Davis and Richard P. Wenzel},
  journal={JAMA},
  year={1995},
  volume={273 2},
  pages={117-23}
}
OBJECTIVE Define the epidemiology of the four recently classified syndromes describing the biologic response to infection: systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock. DESIGN Prospective cohort study with a follow-up of 28 days or until discharge if earlier. SETTING Three intensive care units and three general wards in a tertiary health care institution. METHODS Patients were included if they met at least two of the criteria for SIRS: fever or… CONTINUE READING
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