The natural history of the WRKY–GCM1 zinc fingers and the relationship between transcription factors and transposons

@article{Babu2006TheNH,
  title={The natural history of the WRKY–GCM1 zinc fingers and the relationship between transcription factors and transposons},
  author={M. Madan Babu and Lakshminarayan M. Iyer and Santhanam Balaji and L. Aravind},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={6505 - 6520}
}
WRKY and GCM1 are metal chelating DNA-binding domains (DBD) which share a four stranded fold. Using sensitive sequence searches, we show that this WRKY-GCM1 fold is also shared by the FLYWCH Zn-finger domain and the DBDs of two classes of Mutator-like element (MULE) transposases. We present evidence that they share a stabilizing core, which suggests a possible origin from a BED finger-like intermediate that was in turn ultimately derived from a C2H2 Zn-finger domain. Through a systematic study… CONTINUE READING
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