The natural history of multiple system atrophy: a prospective European cohort study

  title={The natural history of multiple system atrophy: a prospective European cohort study},
  author={Gregor Karl Wenning and Felix Geser and Florian Krismer and Klaus Seppi and Susanne Duerr and Sylvia M. Boesch and Martin K{\"o}llensperger and Georg G{\"o}bel and Karl Peter Pfeiffer and Paolo Barone and M. T. Pellecchia and Niall Quinn and Vasiliki Koukouni and Clare Juliet Fowler and A Schrag and Christopher J. Mathias and Nir Giladi and Tanya Y Gurevich and Erik Dupont and Karen J. Ostergaard and Christer F Nilsson and H{\aa}kan Widner and Wolfgang Hermann Oertel and Karla Maria Eggert and Alberto Albanese and Francesca del Sorbo and Eduardo Tolosa and Adriana V Cardozo and Guenther Deuschl and Helge Hellriegel and Thomas Klockgether and Richard C. Dodel and Cristina Sampaio and Miguel Coelho and Ruth Djaldetti and Eldad Melamed and Thomas Gasser and C Kamm and Giuseppe Meco and C. Colosimo and Olivier Rascol and Wassilios G. Meissner and Francois Tison and Werner Poewe},
  booktitle={The Lancet Neurology},
BACKGROUND Multiple system atrophy (MSA) is a fatal and still poorly understood degenerative movement disorder that is characterised by autonomic failure, cerebellar ataxia, and parkinsonism in various combinations. Here we present the final analysis of a prospective multicentre study by the European MSA Study Group to investigate the natural history of MSA. METHODS Patients with a clinical diagnosis of MSA were recruited and followed up clinically for 2 years. Vital status was ascertained 2… CONTINUE READING