The natural history of degenerative ataxia: a retrospective study in 466 patients.

@article{Klockgether1998TheNH,
  title={The natural history of degenerative ataxia: a retrospective study in 466 patients.},
  author={Thomas Klockgether and Rainer L{\"u}dtke and B Kramer and M. Abele and Katrin B{\"u}rk and Ludger Sch{\"o}ls and Olaf Riess and Franco Laccone and S. Boesch and {\'I}scia Lopes-Cendes and Alexis Brice and Rivka Inzelberg and Nelly Zilber and Johannes Dichgans},
  journal={Brain : a journal of neurology},
  year={1998},
  volume={121 ( Pt 4)},
  pages={
          589-600
        }
}
The aim of the present study was (i) to compare disease progression and survival in different types of degenerative ataxia, and (ii) to identify variables that may modify the rate of disease progression. We included patients suffering from Friedreich's ataxia (FRDA, n = 83), early onset cerebellar ataxia (EOCA, n = 30), autosomal dominant cerebellar ataxia (ADCA) type I (ADCA-I, n = 273), ADCA-III (n = 13) and multiple system atrophy (MSA, n = 67). Molecular genetic testing allowed us to assign… 

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