The natural history of clinical operational tolerance after kidney transplantation through twenty-seven cases.

@article{Brouard2012TheNH,
  title={The natural history of clinical operational tolerance after kidney transplantation through twenty-seven cases.},
  author={Sophie Brouard and Annaick Pallier and Karine Renaudin and Yohann Foucher and Richard Danger and Anne Devys and Anne Cesbron and C Guillot-Guegen and Joanna Ashton-Chess and S{\'e}verine Le Roux and Jean Harb and Gw{\'e}naelle Roussey and J F Subra and Florence Villemain and C H Legendre and Frederieke J Bemelman and Giuseppe Orlando and A Garnier and H Jambon and Herv{\'e} Le Monies De Sagazan and Laura Braun and Christian No{\"e}l and {\'E}vangeline Pillebout and M-C Moal and Carmen Cantarell and Andries Hoitsma and M Ranbant and Antonio Testa and J P Soulillou and Magali Giral},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2012},
  volume={12 12},
  pages={3296-307}
}
We report here on a European cohort of 27 kidney transplant recipients displaying operational tolerance, compared to two cohorts of matched kidney transplant recipients under immunosuppression and patients who stopped immunosuppressive drugs and presented with rejection. We report that a lower proportion of operationally tolerant patients received induction therapy (52% without induction therapy vs. 78.3%[p = 0.0455] and 96.7%[p = 0.0001], respectively), a difference likely due to the higher… CONTINUE READING

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