The natural history of chronic hepatitis C in haemophiliacs.

  title={The natural history of chronic hepatitis C in haemophiliacs.},
  author={Michael Makris and Francis E Preston and Frits R Rosendaal and James C E Underwood and Kenneth M Rice and D. R. Triger},
  journal={British journal of haematology},
  volume={94 4},
Most haemophiliacs treated with non-virally-inactivated clotting factor concentrates have been infected with hepatitis C virus (HCV). We have studied the natural history of chronic HCV infection by following all 138 HCV-positive patients from our centre for periods of up to 28 years. As well as the clinical and biochemical characteristics, we studied 116 liver samples from 63 patients obtained at elective biopsy (n = 103) or autopsy (n = 13). 36 (26%) of the patients were HIV positive, and… CONTINUE READING


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