The natural history of actinic keratosis: a systematic review

@article{Werner2013TheNH,
  title={The natural history of actinic keratosis: a systematic review},
  author={Ricardo Niklas Werner and Adel Sammain and Ricardo Erdmann and Vanessa Hartmann and E Stockfleth and Alexander Nast},
  journal={British Journal of Dermatology},
  year={2013},
  volume={169}
}
Knowledge about the development of untreated actinic keratosis (AK) and risk of progression into squamous cell carcinoma (SCC) is important. Therefore, we set out to synthesize primary data on the natural history of AK. We carried out a systematic literature search (Medline, Medline in Process, Embase, Cochrane) of studies on the natural course of AK, regarding (i) progression and regression rates per lesion‐year, (ii) changes in total lesion counts over time, and (iii) spontaneous field… 
Contemporary management of actinic keratosis
TLDR
The most up-to-date evidence in the management of Actinic keratosis is summarized to mitigate the risk of malignant progression, including metastasis and death.
Current perspective on actinic keratosis: a review
TLDR
Improved agreement among clinicians on AK definition may improve management, and treatments should aim to decrease the risk of KC or facilitate KC diagnosis by reducing the potential for misidentification created when a KC appears in a field of AKs.
Comprehensive management of actinic keratoses: practical integration of available therapies with a review of a newer treatment approach.
TLDR
The major individual approaches to AK treatment based on available literature and common use in clinical practice are ablative therapy, topical field therapy and photodynamic therapy (PDT).6 Liquid nitrogen cryosurgery is the most frequently used ablative approach for AK treatment.
Spontaneous regression rates of actinic keratosis: a systematic review and pooled analysis of randomized controlled trials
TLDR
It is concluded that only a few participants achieve complete regression of their AK without any active treatment and lesion clearance without active treatment is unlikely in OTR, which underline that early and consequent treatment of AK is recommended.
Treatment of Precancers with Topical Agents
TLDR
With the incidence of nonmelanoma skin cancer on the rise, treatment for AKs has been recommended to reduce the development of invasive SCC, to lower healthcare expenditure and for patient well-being.
Actinic keratosis : do we have clinicopathological criteria to select lesions for therapy ?
Actinic keratoses (AKs) are defined clinically as erythematous and scaly plaques occurring on chronically sun-damaged skin as a result to exposure to ultraviolet radiation. They are typically located
Incidence of Actinic Keratosis and Risk of Skin Cancer in Subjects with Actinic Keratosis: A Population-based Cohort Study.
TLDR
This study analysed the incidence of AK and the risk of skin cancer in patients with AK based on data obtained from the National Health Insurance System (NHIS) in South Korea.
Treating actinic keratosis
TLDR
In their randomized controlled phase IIa trial, promising data is presented on the efficacy and safety of a new derivate of ingenol mebutate in the treatment of AK, with the highest concentration of LEO 43204 showing a statistically significantly higher reduction in lesion counts than ingenolmebutate.
Guidelines of care for the management of actinic keratosis.
Treatment considerations in actinic keratosis
  • G. Goldenberg
  • Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2017
TLDR
Therapies with shorter and simpler treatment courses are often associated with better adherence than treatments with longer courses and may represent more appropriate choices in patients for whom convenience and/or adherence are an issue.
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TLDR
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TLDR
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TLDR
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TLDR
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