The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo

@article{Yeh2011TheNC,
  title={The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo},
  author={Ju-ching Yeh and Tereza Cindrova-Davies and Mirella Belleri and Lucia Morbidelli and Nigel Miller and Chin-wen Cho and Kelvin Chan and Yitao Wang and Guo-An Luo and Marina Ziche and Marco Presta and David Stephen Charnock-Jones and Tai-Ping Fan},
  journal={Angiogenesis},
  year={2011},
  volume={14},
  pages={187-197}
}
Radix Angelica sinensis is a Chinese medicinal herb that has been used extensively in the East for the treatment of cardiovascular diseases (CVDs). Angiogenesis plays an important role in the pathogenesis of CVDs. We hypothesized that Radix A. sinensis may contain angiogenesis modulators. In the current study, we investigated the effects of a volatile oil of Radix A. sinensis (VOAS) and n-butylidenephthalide (BP), one of the bioactive components in VOAS, on angiogenesis in vitro and in vivo… CONTINUE READING

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