The natural antioxidant rosmarinic acid spontaneously penetrates membranes to inhibit lipid peroxidation in situ.

@article{Fadel2011TheNA,
  title={The natural antioxidant rosmarinic acid spontaneously penetrates membranes to inhibit lipid peroxidation in situ.},
  author={Oph{\'e}lie Fadel and Karim El Kirat and Sandrine Morandat},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1808 12},
  pages={2973-80}
}
Exogenous molecules from dietary sources such as polyphenols are very efficient in preventing the alteration of lipid membranes by oxidative stress. Among the polyphenols, we have chosen to study rosmarinic acid (RA). We investigated the efficiency of RA in preventing lipid peroxidation and in interacting with lipids. We used liposomes of 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) to show that RA was an efficient antioxidant. By HPLC, we determined that the maximum amount of RA… CONTINUE READING

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