The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors.

@article{Springer2012TheNP,
  title={The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors.},
  author={Jeremy Springer and John Azer and Rui Hua and Courtney Robbins and Andrew J Adamczyk and Sarah McBoyle and Mary Beth Bissell and Robert P. Flood Andrew K. Rose},
  journal={Journal of molecular and cellular cardiology},
  year={2012},
  volume={52 5},
  pages={1122-34}
}
Natriuretic peptides (NPs) are best known for their ability to regulate blood vessel tone and kidney function whereas their electrophysiological effects on the heart are less clear. Here, we measured the effects of BNP and CNP on sinoatrial node (SAN) and atrial electrophysiology in isolated hearts as well as isolated SAN and right atrial myocytes from mice. BNP and CNP dose-dependently increased heart rate and conduction through the heart as indicated by reductions in R-R interval, P wave… CONTINUE READING