The natriuretic activity of the K+ channel blocker U-37883A displays an ADH-dependence.

@article{Clark1998TheNA,
  title={The natriuretic activity of the K+ channel blocker U-37883A displays an ADH-dependence.},
  author={Michael Antony Clark and John A. Lawson and James H. Ludens},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1998},
  volume={20 2},
  pages={
          115-23
        }
}
We reported previously that K+ channel blockers induce diuresis and natriuresis in conscious and anesthetized rats. Free-water clearance studies suggested that K+ channel blockers inhibit NaCl reabsorption in the thick ascending limb (TAL) by blocking K+ recycling through a low-conductance, usually open, apical ATP-sensitive K+ channel. In the present study, we measured the effect of U-37883A (15 mg/kg, i.v.) on Na+ reabsorption in rats preconditioned to alter ADH levels. In water-loaded… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.