The n-3 polyunsaturated fatty acid/dopamine hypothesis of schizophrenia.

  title={The n-3 polyunsaturated fatty acid/dopamine hypothesis of schizophrenia.},
  author={Koichi Ohara},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  volume={31 2},
  • Koichi Ohara
  • Published 2007 in
    Progress in neuro-psychopharmacology & biological…
The dopamine hypothesis of schizophrenia has been the most influential since the 1970s. Normally, the prefrontal dopamine system suppressively controls the limbic dopamine system. Since the activities of prefrontal dopaminergic neurons are reduced in schizophrenia, the suppressive effect of the prefrontal area on the limbic system is reduced, and activities of the limbic dopamine system are enhanced. Reduced activities of the prefrontal dopamine system contribute to negative symptoms and… CONTINUE READING


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