The mysterious trace amines: Protean neuromodulators of synaptic transmission in mammalian brain

@article{Burchett2006TheMT,
  title={The mysterious trace amines: Protean neuromodulators of synaptic transmission in mammalian brain},
  author={Scott A. Burchett and T. Philip Hicks},
  journal={Progress in Neurobiology},
  year={2006},
  volume={79},
  pages={223-246}
}
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192 Citations

Trace Amines and Their Relevance to Neurological Disorders
Electrophysiological Effects of Trace Amines on Mesencephalic Dopaminergic Neurons
TLDR
Three important new aspects of TAs action have recently emerged: inhibition of firing due to increased release of dopamine; reduction of D2 and GABAB receptor-mediated inhibitory responses (excitatory effects due to disinhibition); and a direct activation of GIRK channels by TA1 receptors which produce cell membrane hyperpolarization.
Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications
TLDR
TAAR1 is uniquely positioned to exert direct control over DA and 5-HT neuronal firing and release, which has profound implications for understanding the pathophysiology of, and therefore designing more efficacious therapeutic interventions for, a range of neuropsychiatric disorders that involve aminergic dysregulation.
Anatomical and functional evidence for trace amines as unique modulators of locomotor function in the mammalian spinal cord
The trace amines (TAs), tryptamine, tyramine, and β-phenylethylamine, are synthesized from precursor amino acids via aromatic-L-amino acid decarboxylase (AADC). We explored their role in the…
Trace Amines and Their Relevance to Psychiatry and Neurology: A Brief Overview
TLDR
There has been a resurgence of interest in these amines in the past decade with the discovery and cloning of a unique family of G-protein-coupled receptors, some of which are selectively activated by trace amines; these receptors have been termed trace amine, associated receptors (TAARs).
Trace Amine Receptors and Mood Disorders
Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics
Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs
TLDR
It is found that the TAAR1 pseudogenization event resulted in an uncompensated loss of function in dogs and was predated the emergence of the Canini tribe rather than being coincident with canine domestication.
Investigation of trace amine receptors in the cardiovascular systems
TLDR
The molecular biological confirmation of the presence of TAAR1 and the pharmacological findings regarding the effects of TAs in rat aortic rings might explain their hypertensive effects and their role in coronary heart disease and migraine headache.
The vascular effects of trace amines and amphetamines.
  • K. Broadley
  • Biology, Chemistry
    Pharmacology & therapeutics
  • 2010
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Previous studies showing responses to physiologically relevant concentrations of trace amines are reviewed, along with those showing a reciprocal relationship between trace amine levels and fluctuations in basal monoaminergic tone, and it is hypothesized that the traceAmines function as endogenous neuromodulators of classical monoamine neurotransmitters.
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