The mysterious trace amines: Protean neuromodulators of synaptic transmission in mammalian brain

@article{Burchett2006TheMT,
  title={The mysterious trace amines: Protean neuromodulators of synaptic transmission in mammalian brain},
  author={Scott A. Burchett and T. Philip Hicks},
  journal={Progress in Neurobiology},
  year={2006},
  volume={79},
  pages={223-246}
}
The trace amines are a structurally related group of amines and their isomers synthesized in mammalian brain and peripheral nervous tissues. They are closely associated metabolically with the dopamine, noradrenaline and serotonin neurotransmitter systems in mammalian brain. Like dopamine, noradrenaline and serotonin the trace amines have been implicated in a vast array of human disorders of affect and cognition. The trace amines are unique as they are present in trace concentrations, exhibit… Expand
View on Elsevier
doi.org
183 Citations
Highly Influential Citations
4
Background Citations
68
Methods Citations
2

183 Citations

Citation Type

Citation Type

Trace Amines and Their Relevance to Neurological Disorders
TLDR
This commentary focuses on the possible link among monoaminergic neurotransmitters, trace amines, and neurological disorders, having a common symptom of depression. Expand
Electrophysiological Effects of Trace Amines on Mesencephalic Dopaminergic Neurons
TLDR
Three important new aspects of TAs action have recently emerged: inhibition of firing due to increased release of dopamine; reduction of D2 and GABAB receptor-mediated inhibitory responses (excitatory effects due to disinhibition); and a direct activation of GIRK channels by TA1 receptors which produce cell membrane hyperpolarization. Expand
Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications
TLDR
TAAR1 is uniquely positioned to exert direct control over DA and 5-HT neuronal firing and release, which has profound implications for understanding the pathophysiology of, and therefore designing more efficacious therapeutic interventions for, a range of neuropsychiatric disorders that involve aminergic dysregulation. Expand
The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) in central nervous system.
TLDR
Findings are discussed that provide insights into the functional roles of human trace amines (including P-Octopamine, β phenylethylamine, Tryptamine, Tyramine, Synephrine, 3-Iodothyronamine, N-Methyltyramine) in brain and the known functions of human Trace amine receptors in brain. Expand
Anatomical and functional evidence for trace amines as unique modulators of locomotor function in the mammalian spinal cord
The trace amines (TAs), tryptamine, tyramine, and β-phenylethylamine, are synthesized from precursor amino acids via aromatic-L-amino acid decarboxylase (AADC). We explored their role in the… Expand
Trace Amines and Their Relevance to Psychiatry and Neurology: A Brief Overview
The arylalkylamines, s-phenylethylamine, m- and p-tyramine, tryptamine, m- and p-octopamine, phenylethanolamine and synephrine, have been termed trace amines because of their low absolute… Expand
Brain-Specific Overexpression of Trace Amine-Associated Receptor 1 Alters Monoaminergic Neurotransmission and Decreases Sensitivity to Amphetamine
TLDR
Overall, these data show that Taar1 brain overexpression causes hyposensitivity to amphetamine and alterations of monoaminergic neurotransmission and suggest that in vivo the receptor is either constitutively active and/or tonically activated by ambient levels of endogenous agonist(s). Expand
Trace Amine Receptors and Mood Disorders
Abstract Trace amines (TAs) such as p-tyramine, tryptamine, octopamine, and β-phenylethylamine are synthesized from amino acid precursors by aromatic amino acid decarboxylase and are enzymatically… Expand
Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics
TLDR
With the first potent and selective TAAR1 partial agonist, RO5203648, it is shown that TAar1 is implicated in a broad range of relevant physiological, behavioral, and cognitive neuropsychiatric dimensions and suggest that agonists at this receptor might have therapeutic potential in one or more Neuropsychiatric domains. Expand
Interaction of the Dopaminergic and Serotonergic Systems in Rat Brain
TLDR
The role of 5-HT neurons in the striatal dopaminergic imbalance that is responsible for the rotational behavior seen in the unilateral 6-OHDA rat is highlighted. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 299 REFERENCES
Trace amines and alternative neurotransmitters in the central nervous system.
TLDR
It is now apparent that its turnover in most neuronal tissues is very rapid, and based on the production of deaminated metabolites, the daily synthesis of octopamine in the whole body closely approaches that of the catecholamines. Expand
Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators
  • M. D. Berry
  • Chemistry, Medicine
  • Journal of neurochemistry
  • 2004
TLDR
Previous studies showing responses to physiologically relevant concentrations of trace amines are reviewed, along with those showing a reciprocal relationship between trace amine levels and fluctuations in basal monoaminergic tone, and it is hypothesized that the traceAmines function as endogenous neuromodulators of classical monoamine neurotransmitters. Expand
Tryptamine: a neuromodulator or neurotransmitter in mammalian brain?
  • R. Jones
  • Medicine, Biology
  • Progress in Neurobiology
  • 1982
TLDR
Whatever the role of tryptamine in the CNS it is clear that it not simply present as an accident of metabolism or a "biological artefact," the indications are that it possesses important functions in central neurotransmission. Expand
Trace amines: Identification of a family of mammalian G protein-coupled receptors
  • B. Borowsky, N. Adham, +14 authors C. Gerald
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
TLDR
Using a degenerate PCR approach, 15 G protein-coupled receptors (GPCR) from human and rodent tissues are identified and it is demonstrated that two of these receptors bind and/or are activated by trace amines. Expand
Inhibitory effects of trace amines on rat midbrain dopaminergic neurons
TLDR
The data suggest that trace amines cause an indirect activation of dopamine autoreceptors, by an increased efflux of newly synthesised dopamine. Expand
Iontophoretic studies of some trace amines in the mammalian CNS
It has been suggested that some of the trace amines, [p-tyramine (p-TA), poctopamine (p-OA), fl-phenylethylamine (PE) and phenylethanolamine (PEO)] may act as coor false neurotransmitters,… Expand
Brain Trace Amines: Mapping Studies and Effects of Mesencephalic Lesions
The brain trace amine concentration has been estimated by different research groups and extends over a wide range of values; the general tendency, however, has been towards the confirmation of the… Expand
A renaissance in trace amines inspired by a novel GPCR family.
TLDR
The recent discovery of a novel family of G-protein-coupled receptors that includes individual members that are highly specific for TAs indicates a potential role forTAs as vertebrate neurotransmitters or neuromodulators, although the majority of these GPCRs so far have not been demonstrated to be activated by TAs. Expand
Analysis of Trace Amines: Endogenous Levels and the Effects of Various Drugs on Tissue Concentrations in the Rat
The trace amines phenylethylamine (PE), p-tyramine (p-TA), m-tyramine (m-TA) and tryptamine (T) have been analyzed as their dansyl derivatives by the highly specific and sensitive integrated ion… Expand
Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor.
TLDR
The discovery and pharmacological characterization of a rat G protein-coupled receptor that stimulates the production of cAMP when exposed to the trace amines p-tyramine, beta-phenethylamine, tryptamine, and octopamine and the discovery that amphetamines are potent rTAR1 agonists suggests that the effects of these widely used drugs may be mediated in part by this receptor as well as their previously characterized targets, the neurotransmitter transporter proteins. Expand
...
1
2
3
4
5
...