The mysteries of induced pluripotency: where will they lead?

  title={The mysteries of induced pluripotency: where will they lead?},
  author={Andras D Nagy and Kristina Vintersten Nagy},
  journal={Nature Methods},
differentiated somatic cells. The power of transcription factors for this purpose was first demonstrated more than 20 years ago, when it was shown that expression of a single transcription factor (Myod) could convert a fibroblast to a myoblast9. This finding, and the approach taken, were the precursor to Shinya Yamanaka’s work, which led him a few years ago to the identification of four factors capable of reprogramming adult somatic cells to what he called induced pluripotency10. This… CONTINUE READING

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