The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells.

@article{Chen1999TheMD,
  title={The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells.},
  author={X. Q. Chen and Ivan Tan and Thy Leung and Louis Lim},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 28},
  pages={
          19901-5
        }
}
  • X. Q. Chen, Ivan Tan, +1 author Louis Lim
  • Published in
    The Journal of biological…
    1999
  • Biology, Medicine
  • The myotonic dystrophy kinase-related Cdc42-binding kinase (MRCKalpha) has been implicated in the morphological activities of Cdc42 in nonneural cells. Both MRCKalpha and the kinase-related Rho-binding kinase (ROKalpha) are involved in nonmuscle myosin light-chain phosphorylation and associated actin cytoskeleton reorganization. We now show that in PC12 cells, overexpression of the kinase domain of MRCKalpha and ROKalpha resulted in retraction of neurites formed on nerve growth factor (NGF… CONTINUE READING

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