The myotonic dystrophies: molecular, clinical, and therapeutic challenges.


Myotonic dystrophy is the most common type of muscular dystrophy in adults and is characterised by progressive myopathy, myotonia, and multiorgan involvement. Two genetically distinct entities have been identified. Myotonic dystrophy type 1 (also known as Steinert's disease) was first described more than 100 years ago, whereas myotonic dystrophy type 2 was… (More)
DOI: 10.1016/S1474-4422(12)70204-1


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