The myostatin gene: an overview of mechanisms of action and its relevance to livestock animals

  title={The myostatin gene: an overview of mechanisms of action and its relevance to livestock animals},
  author={Daniela Aiello and Ketan Patel and Emiliano Lasagna},
  journal={Animal Genetics},
Myostatin, also known as growth differentiation factor 8, a member of the transforming growth factor-beta super-family, is a negative regulator of muscle development. Myostatin acts at key points during pre- and post-natal life of amniotes that ultimately determine the overall muscle mass of an animal. Mutations have already demonstrated the impact of attenuating myostatin activity on muscle development. A number of large animals, including cattle, sheep, dogs and humans, display the 'double… 

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