The myosin-I-binding protein Acan125 binds the SH3 domain and belongs to the superfamily of leucine-rich repeat proteins.

@article{Xu1997TheMP,
  title={The myosin-I-binding protein Acan125 binds the SH3 domain and belongs to the superfamily of leucine-rich repeat proteins.},
  author={Pingxi Xu and Kenneth I. Mitchelhill and Bostjan Kobe and Bruce E. Kemp and Henry G. Zot},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 8},
  pages={3685-90}
}
The SH3 domains of src and other nonreceptor tyrosine kinases have been shown to associate with the motif PXXP, where P and X stand for proline and an unspecified amino acid, but a motif that binds to the SH3 domain of myosin has thus far not been characterized. We previously showed that the SH3 domain of Acanthamoeba myosin-IC interacts with the protein Acan125. We now report that the Acan125 protein sequence contains two tandem consensus PXXP motifs near the C terminus. To test for binding… CONTINUE READING

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