The myeloperoxidase gene in Alzheimer's disease: a case-control study and meta-analysis.

@article{Combarros2002TheMG,
  title={The myeloperoxidase gene in Alzheimer's disease: a case-control study and meta-analysis.},
  author={Onofre Combarros and Jon Infante and Javier Llorca and Nicol{\'a}s Pe{\~n}a and Carlos Fern{\'a}ndez-Viadero and Jos{\'e} Berciano},
  journal={Neuroscience letters},
  year={2002},
  volume={326 1},
  pages={33-6}
}
Myeloperoxidase (MPO) presence has been demonstrated in microglia associated with senile plaques, and contributes to Alzheimer's disease (AD) pathology through oxidation-induced damage. Recently, a functional biallelic (G/A) polymorphism in the promotor region (-463) of the MPO gene has been associated with susceptibility to AD, but the reports of this association have been inconsistent. A case-control study utilizing a clinically well-defined group of 315 sporadic AD patients and 327 control… CONTINUE READING