The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis.

@article{Frosch2009TheMP,
  title={The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis.},
  author={Michael Frosch and Martina Ahlmann and Thomas Vogl and Helmut Wittkowski and Nico Wulffraat and Dirk Foell and Johannes Roth},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 3},
  pages={883-91}
}
OBJECTIVE Fever of unknown origin is a diagnostic challenge in children, especially for differentiation of systemic-onset juvenile idiopathic arthritis (systemic-onset JIA) and infectious diseases. We undertook this study to analyze the relevance of myeloid-related proteins (MRPs) 8 and 14, endogenous activators of Toll-like receptor 4, in diagnosis and pathogenesis of systemic-onset JIA. METHODS Serum concentrations of MRP-8/MRP-14 were analyzed in 60 patients with systemic-onset JIA, 85… CONTINUE READING

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