The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole.

@article{Prajna2013TheMU,
  title={The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole.},
  author={Namperumalsamy Venkatesh Prajna and Tiruvengada Krishnan and Jeena Mascarenhas and Revathi Rajaraman and Lalitha Prajna and Muthiah Srinivasan and Anita Raghavan and Catherine E Oldenburg and Kathryn J. Ray and Michael E Zegans and Stephen D. McLeod and Travis C. Porco and Nisha R Acharya and Thomas M. Lietman},
  journal={JAMA ophthalmology},
  year={2013},
  volume={131 4},
  pages={422-9}
}
OBJECTIVE To compare topical natamycin vs voriconazole in the treatment of filamentous fungal keratitis. METHODS This phase 3, double-masked, multicenter trial was designed to randomize 368 patients to voriconazole (1%) or natamycin (5%), applied topically every hour while awake until reepithelialization, then 4 times daily for at least 3 weeks. Eligibility included smear-positive filamentous fungal ulcer and visual acuity of 20/40 to 20/400. MAIN OUTCOME MEASURES The primary outcome was… CONTINUE READING
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