The mutual dependence between bone and gonads.

@article{Karsenty2012TheMD,
  title={The mutual dependence between bone and gonads.},
  author={Gerard Karsenty},
  journal={The Journal of endocrinology},
  year={2012},
  volume={213 2},
  pages={107-14}
}
It has long been known that sex steroid hormones regulate bone mass accrual. This observation raises the testable hypothesis that bone may in turn regulate the synthesis and secretion of sex steroid hormones in one or both genders. This hypothesis is comprised within a more general hypothesis that bone mass, energy metabolism, and reproduction are regulated coordinately. The identification of osteocalcin as an osteoblast-specific secreted molecule allows us to address this question in molecular… CONTINUE READING
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