• Corpus ID: 32836359

The mutational load with epistatic gene interactions in fitness.

  title={The mutational load with epistatic gene interactions in fitness.},
  author={Motoo Kimura and Takeo Maruyama},
  volume={54 6},
HE mutational load is defined as the proportion by which the population (CROW 1958). In a very large population, where the mutant genes are kept in low frequencies by the balance between mutation and selection, it represents the intensity of natural selection at the genotypic level. The mutational load in a large population was first calculated by HALDANE (1937) without assuming an epistatic component in fitness. Later, a similar but more detailed calculation was carried out by KIMURA (1961… 

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