The mutational landscape of head and neck squamous cell carcinoma.

  title={The mutational landscape of head and neck squamous cell carcinoma.},
  author={Nicolas Stransky and Ann Marie Egloff and Aaron D Tward and Aleksandar D. Kostic and Kristian Cibulskis and Andrey Sivachenko and Gregory V. Kryukov and Michael Sohn Lawrence and Carrie L. Sougnez and Aaron McKenna and Erica Shefler and Alex H. Ramos and Petar Stojanov and Scott L. Carter and Douglas Voet and Maria L. Cort{\'e}s and Daniel Auclair and Michael F. Berger and Gordon Saksena and Candace Guiducci and Robert C. Onofrio and Melissa Parkin and Marjorie Romkes and Joel L. Weissfeld and Raja R Seethala and Lin Wang and Claudia Rangel-Escare{\~n}o and Juan C. Fern{\'a}ndez-L{\'o}pez and Alfredo Hidalgo-Miranda and Jorge Melendez-Zajgla and Wendy Winckler and Kristin G. Ardlie and Stacey Bolk Gabriel and Matthew Meyerson and Eric S. Lander and Gad Getz and Todd R. Golub and Levi A. Garraway and Jennifer R Grandis},
  volume={333 6046},
Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing data from 74 tumor-normal pairs. The majority exhibited a mutational profile consistent with tobacco exposure; human papillomavirus was detectable by sequencing DNA from infected tumors. In addition to identifying previously known HNSCC genes (TP53, CDKN2A, PTEN, PIK3CA, and HRAS), our analysis revealed many genes not… CONTINUE READING
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Arch Otolaryngol Head Neck Surg

  • DI Kutler
  • 2003

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