The mutation spectrum revealed by paired genome sequences from a lung cancer patient

  title={The mutation spectrum revealed by paired genome sequences from a lung cancer patient},
  author={William Lee and Zhaoshi Jiang and Jinfeng Liu and Peter M. Haverty and Yinghui Guan and Jeremy Stinson and Peng Yue and Yan Zhang and Krishna Prasad Pant and Deepali Bhatt and Connie Ha and Stephanie Johnson and Michael I. Kennemer and Sankar Mohan and Igor Nazarenko and Colin K. Watanabe and Andrew B. Sparks and David S. Shames and Robert Gentleman and Frederic j. de Sauvage and Howard M. Stern and Ajay Pandita and Dennis Ballinger and R. Drmanac and Zora Modru{\vs}an and Somasekar Seshagiri and Zemin Zhang},
Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small-cell lung carcinomas in smokers being the predominant form of the disease. Although previous studies have identified important common somatic mutations in lung cancers, they have primarily focused on a limited set of genes and have thus provided a constrained view of the mutational spectrum. Recent cancer sequencing efforts have used next-generation sequencing technologies to provide a genome-wide view of… 

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