The mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1

@article{Weiss2008TheMO,
  title={The mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1},
  author={Heike Weiss and Tanja Arndt and Anne Joerns and Sigurd Lenzen and Edwin Cuppen and Hans J{\"u}rgen Hedrich and Markus Tiedge and Dirk Wedekind},
  journal={Mammalian Genome},
  year={2008},
  volume={19},
  pages={292-297}
}
The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes mellitus (T1DM) with an autosomal recessive mode of inheritance. T1DM susceptibility loci could be localized on chromosome (RNO) 20 in the major histocompatibility complex region (Iddm1) and on RNO1 (Iddm8, Iddm9) in a BN backcross cohort. In this study the impact of the different susceptibility regions on diabetes development was investigated in a backcross population of the diabetes-resistant PAR strain. A cohort of 130 [(PAR… CONTINUE READING
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