The mutation Ala677-->Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis.

@article{Arruda1997TheMA,
  title={The mutation Ala677-->Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis.},
  author={V. Arruda and P. M. von Zuben and L. C. Chiaparini and J. Annichino-Bizzacchi and F. Costa},
  journal={Thrombosis and haemostasis},
  year={1997},
  volume={77 5},
  pages={
          818-21
        }
}
  • V. Arruda, P. M. von Zuben, +2 authors F. Costa
  • Published 1997
  • Medicine
  • Thrombosis and haemostasis
  • Mild hyperhomocysteinemia has been identified as a risk factor for arterial disease and for venous thrombosis. Individuals homozygous for the thermolabile variant of the methylene tetrahydrofolate reductase gene (MTHFR) which results from a common mutation Ala677-->Val and is found in 5-15% of the general population, have significantly elevated plasma homocysteine levels and may account for one of the genetic risk factors in vascular disease. We have analyzed the prevalence of MTHFR-T… CONTINUE READING
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