The mutation Ala677-->Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis.

@article{Arruda1997TheMA,
  title={The mutation Ala677-->Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis.},
  author={Valder R Arruda and P M von Zuben and L C Chiaparini and Joyce Maria Annichino-Bizzacchi and Fernando F. Costa},
  journal={Thrombosis and haemostasis},
  year={1997},
  volume={77 5},
  pages={
          818-21
        }
}
Mild hyperhomocysteinemia has been identified as a risk factor for arterial disease and for venous thrombosis. Individuals homozygous for the thermolabile variant of the methylene tetrahydrofolate reductase gene (MTHFR) which results from a common mutation Ala677-->Val and is found in 5-15% of the general population, have significantly elevated plasma homocysteine levels and may account for one of the genetic risk factors in vascular disease. We have analyzed the prevalence of MTHFR-T… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 105 CITATIONS, ESTIMATED 57% COVERAGE

Thrombophilic Gene Mutations in Relation to Different Manifestations of Venous Thromboembolism: A Single Tertiary Center Study

VIEW 1 EXCERPT
CITES BACKGROUND

Uncertain thrombophilia markers.

VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

1998
2019

CITATION STATISTICS

  • 1 Highly Influenced Citations