The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum

Abstract

The Moonwalker (Mwk) mouse is a model of dominantly inherited cerebellar ataxia caused by a gain-of-function mutation in the transient receptor potential (TRP) channel TRPC3. Here, we report impairments in dendritic growth and synapse formation early on during Purkinje cell development in the Mwk cerebellum that are accompanied by alterations in calcium… (More)
DOI: 10.1093/hmg/ddv150

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