The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV.

@article{KuhfittigKulle2007TheMP,
  title={The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV.},
  author={Steffi Kuhfittig-Kulle and Elke Feldmann and Andrea Odersky and Aneta Kuliczkowska and Wolfgang Goedecke and Angelika Eggert and Petra Pfeiffer},
  journal={Mutagenesis},
  year={2007},
  volume={22 3},
  pages={217-33}
}
Non-homologous end joining (NHEJ), the major pathway of double-strand break (DSB) repair in mammalian cells, comprises two subpathways: one that requires the three core factors Ku70/80, DNA-PKcs and XRCC4/LigIV (DNA-PK-dependent NHEJ) and the other that is independent of these factors. Using a cell-free NHEJ assay, we have investigated the ability of three Chinese hamster ovary (CHO) mutants deficient in Ku80 (xrs6), DNA-PKcs (XR-C1) and XRCC4 (XR-1) in comparison with CHO-K1 wild-type cells to… CONTINUE READING
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