The mutagenic effects of low level sub-acute inhalation exposure to benzene in CD-1 mice.

@article{Ward1992TheME,
  title={The mutagenic effects of low level sub-acute inhalation exposure to benzene in CD-1 mice.},
  author={Jonathan B Ward and Marinel M Ammenheuser and V. M. Sadagopa Ramanujam and Debra L Morris and Elbert B. Whorton and Marvin S. Legator},
  journal={Mutation research},
  year={1992},
  volume={268 1},
  pages={49-57}
}
Benzene is a widely used chemical and common environmental contaminant. It is carcinogenic in man and animals and is genotoxic in mice, rats, and occupationally exposed humans at doses above one part per million. In order to evaluate the genotoxic effects of prolonged exposures to very low concentrations of benzene, we exposed CD-1 mice to benzene by inhalation for 22 h per day, seven days per week for six weeks at 40, 100 and 1000 parts per billion (ppb). Additional groups were exposed to… CONTINUE READING