The mutagenic constituents of Rubia tinctorum.

  title={The mutagenic constituents of Rubia tinctorum.},
  author={Yoko Kawasaki and Yukihiro Goda and Kunitoshi Yoshihira},
  journal={Chemical \& pharmaceutical bulletin},
  volume={40 6},
Twenty compounds were isolated from the roots of Rubia tinctorum which are used as a commercial source of madder color. Among these compounds, mollugin (1), 1-hydroxy-2-methylanthraquinone (2), 2-ethoxymethylanthraquinone(11), rubiadin (13), 1,3-dihydroxyanthraqunone (14), 7-hydroxy-2-methylanthraquinone (16), lucidin (17), 1-methoxymethylanthraquinone (18) and lucidin-3-O-primeveroside (19) showed mutagenicity with Salmonella typhimurium TA 100 and/or TA 98. Since the mutagenic compounds… 
Two new steroidal alkaloids from the roots of Sarcococca ruscifolia
  • K. He, Jiang Du
  • Chemistry
    Journal of Asian natural products research
  • 2010
Two new steroidal alkaloids are isolated from the roots of Sarcococca ruscifolia and their structures were elucidated on the basis of NMR and MS data, and the relative stereochemistry of 1 was finally determined by X-ray crystallographic analysis.
Cytotoxic anthraquinones from the stems of Rubia wallichiana Decne.
Three compounds, namely rubiawallin-A, -B, and -C, constitute the first report of their occurrence from the natural source and demonstrate most effective cytotoxicity towards Hepa-3B and Colo-205 cells.
Protection against Trp-P-2 mutagenicity by purpurin: mechanism of in vitro antimutagenesis.
In vitro the proposed mechanism by which purpurin protects against heterocyclic amine-induced mutagenesis involves competitive inhibition of cytochrome P450-dependent bioactivation and accelerated degradation of the N-hydroxylamine to the parent amine.
Anthraquinones of the Roots of Pentas micrantha
Isolation of a munjistin derivative from the genus Pentas, used in the East African indigenous medicine to treat malaria, showed low antiplasmodial activities.
Chemical structure determination of DNA bases modified by active metabolites of lucidin-3-O-primeveroside.
The precise determination of the modified DNA bases generated by LuP and the method for their analysis may contribute to further comprehension of the mode of action underlying carcinogenesis by MR and related anthraquinones.
Synthesis and antitubercular activity of substituted novel pyrazoline derivatives
A series of 2-2-methoxy-4-[5-(substituted phenyl)1-(4-pyridylcarbonyl)-4,5-dihydro-1H-3-pyrazolyl] phenoxyacetic acid synthesized by the reaction between isoniazid (INH) and chalcones was found to be most active agent against M. tuberculosis (INHR-MTB).
Pharmacological and toxicological activity of Heterophyllaea pustulata anthraquinone extracts.
Benzenic extracts from both stems and leaves of Heterophyllaea pustulata showed the most significant activity in vivo in the Brine Shrimp Lethally Test (BST), relative to others of different