The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity.

@article{Hanai2007TheMU,
  title={The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity.},
  author={Jun-ichi Hanai and Peirang Cao and Preeti Tanksale and Shintaro Imamura and Eriko Koshimizu and Jinghui Zhao and Shuji Kishi and Michiaki Yamashita and Paul Stewart Phillips and Vikas P. Sukhatme and Stewart H. Lecker},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 12},
  pages={
          3940-51
        }
}
Statins inhibit HMG-CoA reductase, a key enzyme in cholesterol synthesis, and are widely used to treat hypercholesterolemia. These drugs can lead to a number of side effects in muscle, including muscle fiber breakdown; however, the mechanisms of muscle injury by statins are poorly understood. We report that lovastatin induced the expression of atrogin-1, a key gene involved in skeletal muscle atrophy, in humans with statin myopathy, in zebrafish embryos, and in vitro in murine skeletal muscle… CONTINUE READING

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