The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

@article{Yang2007TheMM,
  title={The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2},
  author={B. Yang and Huixian Lin and Jiening Xiao and Y. Lu and Xiaobin Luo and Baoxin Li and Y. Zhang and Chaoqian Xu and Y. Bai and H. Wang and Guohao Chen and Z. Wang},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={486-491}
}
  • B. Yang, Huixian Lin, +9 authors Z. Wang
  • Published 2007
  • Medicine
  • Nature Medicine
  • MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene silencing by annealing to inexactly complementary sequences in the 3′-untranslated regions of target mRNAs. Our current understanding of the functions of miRNAs relies mainly on their tissue-specific or developmental stage-dependent expression and their evolutionary conservation, and therefore is primarily limited to their involvement in developmental regulation and… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 28 REFERENCES
    Silencing of microRNAs in vivo with ‘antagomirs’
    • 3,551
    • PDF