The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system

@article{Carta2006TheMR,
  title={The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system},
  author={Mario Carta and Luca Murru and Paolo Botta and Giuseppe Talani and GianPietro Sechi and Pier Luigi De Riu and Enrico Sanna and Giovanni Biggio},
  journal={Neuropharmacology},
  year={2006},
  volume={51},
  pages={805-815}
}
Thiocolchicoside (TCC) is used clinically for its muscle relaxant, anti-inflammatory, and analgesic properties, and it has been shown to interact with gamma-aminobutyric acid (GABA) type A receptors (GABAARs) and strychnine-sensitive glycine receptors in the rat central nervous system. In contrast to a proposed agonistic action at these two types of inhibitory receptors, pharmacological evidence has shown that, under certain conditions, TCC manifests convulsant activity in animals and humans… 
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TLDR
An automated marker-free cell imaging method, based on digital holographic microscopy (DHM), which allows the automatically screening of compounds in multiple plates without having to label the cells or use special plates, demonstrates the applicability of this screening by imaging method for the discovery of new chemical structures.
New derivative spectrophotometric methods for the determination of thiocolchicoside – A semisynthetic derivative of colchicoside
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These zero-order and first derivative spectrophotometric techniques can be successfully applied for the estimation of thiocolchicoside in pharmaceutical dosage forms and are simple and economical.
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