The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.

@article{Okada2006TheMP,
  title={The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.},
  author={Kumiko Okada and Akane Inoue and Momoko Okada and Yoji Murata and Shigeru Kakuta and Takafumi Jigami and Sachiko Kubo and Hirokazu Shiraishi and Katsumi Eguchi and Masakatsu Motomura and Tetsu Akiyama and Yoichiro Iwakura and Osamu Higuchi and Yuji Yamanashi},
  journal={Science},
  year={2006},
  volume={312 5781},
  pages={1802-5}
}
The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the clustering of receptors for the neurotransmitter acetylcholine. Upon innervation, neural agrin activates MuSK to establish the postsynaptic apparatus, although agrin-independent formation of neuromuscular synapses can also occur experimentally in the absence of neurotransmission. Dok-7, a MuSK-interacting cytoplasmic protein, is essential for MuSK… CONTINUE READING
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