The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.

  title={The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.},
  author={Kumiko Okada and Akane Inoue and Momoko Okada and Yoji Murata and Shigeru Kakuta and Takafumi Jigami and Sachiko Kubo and Hirokazu Shiraishi and Katsumi Eguchi and Masakatsu Motomura and Tetsu Akiyama and Yoichiro Iwakura and Osamu Higuchi and Yuji Yamanashi},
  volume={312 5781},
The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the clustering of receptors for the neurotransmitter acetylcholine. Upon innervation, neural agrin activates MuSK to establish the postsynaptic apparatus, although agrin-independent formation of neuromuscular synapses can also occur experimentally in the absence of neurotransmission. Dok-7, a MuSK-interacting cytoplasmic protein, is essential for MuSK… CONTINUE READING
Highly Influential
This paper has highly influenced 20 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 158 extracted citations

Congenital myasthenic syndromes.

Handbook of clinical neurology • 2008
View 20 Excerpts
Highly Influenced

The role of MuSK in synapse formation and neuromuscular disease.

Cold Spring Harbor perspectives in biology • 2013
View 6 Excerpts
Highly Influenced

Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2008
View 6 Excerpts
Highly Influenced

Phenotypical spectrum of DOK7 mutations in congenital myasthenic syndromes.

Brain : a journal of neurology • 2007
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…