The muscarinic receptor antagonist propiverine exhibits α1-adrenoceptor antagonism in human prostate and porcine trigonum

  title={The muscarinic receptor antagonist propiverine exhibits $\alpha$1-adrenoceptor antagonism in human prostate and porcine trigonum},
  author={M. Wuest and L. Witte and M. Michel-Reher and S. Propping and M. Braeter and G. Strugala and M. Wirth and M. Michel and U. Ravens},
  journal={World Journal of Urology},
  pages={149 - 155}
PurposeCombination therapy of male lower urinary tract symptoms with α1-adrenoceptor and muscarinic receptor antagonists attracts increasing interest. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca2+ channels. Here, we have investigated whether propiverine and its metabolites can additionally antagonize α1-adrenoceptors.MethodsHuman prostate and porcine trigone muscle strips were used to explore inhibition of α1-adrenoceptor-mediated… Expand
Editorial Comment from Dr Negoro to Propiverine increases urethral wall catecholamine levels and bladder leak point pressure in rats
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