The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells.

@article{Herskowitz2005TheMG,
  title={The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells.},
  author={Jeremy H Herskowitz and Meagan A. Jacoby and Samuel H Speck},
  journal={Journal of virology},
  year={2005},
  volume={79 4},
  pages={
          2261-73
        }
}
Murine gammaherpesvirus 68 (gammaHV68) infection of mice provides a tractable small-animal model system for assessing the requirements for the establishment and maintenance of gammaherpesvirus latency within the lymphoid compartment. The M2 gene product of gammaHV68 is a latency-associated antigen with no discernible homology to any known proteins. Here we focus on the requirement for the M2 gene in splenic B-cell latency. Our analyses showed the following. (i) Low-dose (100 PFU) inoculation… CONTINUE READING

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