The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes.

@article{Schbeler2001TheMB,
  title={The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes.},
  author={Dirk Sch{\"u}beler and Mark Groudine and Michael A. Bender},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 20},
  pages={11432-7}
}
Locus control regions (LCRs) are defined by their ability to confer high-level tissue-specific expression to linked genes in transgenic assays. Previously, we reported that, at its native site, the murine beta-globin LCR is required for high-level beta-globin gene expression, but is not required to initiate an open chromatin conformation of the locus. To further investigate the mechanism of LCR-mediated transcriptional enhancement, we have analyzed allele-specific beta-globin expression and the… CONTINUE READING

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