The murine VpreB1 and VpreB2 genes both encode a protein of the surrogate light chain and are co-expressed during B cell development.

@article{Dul1996TheMV,
  title={The murine VpreB1 and VpreB2 genes both encode a protein of the surrogate light chain and are co-expressed during B cell development.},
  author={Jeanne L. Dul and Yair Argon and Thomas Winkler and Edwin ten Boekel and Fritz Georg Melchers and Inga-Lill M{\aa}rtensson},
  journal={European journal of immunology},
  year={1996},
  volume={26 4},
  pages={906-13}
}
The surrogate light chain is composed of two polypeptides, VpreB and lambda 5. In the mouse there are two VpreB genes which are 99% identical within the coding regions. Extensive restriction enzyme mapping and sequencing of these two genes showed that only the coding region and immediate 5' and 3' flanking sequences exhibited such high homology. More distal sequences have diverged considerably. The region 5' of the respective gene directed transcription of a reporter gene in a pre-B cell line… CONTINUE READING

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