The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development.

@article{Campbell2005TheMC,
  title={The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development.},
  author={Sandra J. Campbell and Colin J. Henderson and Daniel C. Anthony and Duncan Davidson and Anthony John Clark and C. R. Wolf},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 7},
  pages={5828-35}
}
In adult mice the cytochrome P450 Cyp1a1 gene is not constitutively expressed but is highly inducible by foreign compounds acting through the aryl hydrocarbon (Ah) receptor. However, the expression profile of the Cyp1a1 gene in the developing embryo is not well under-stood. Using established transgenic mouse lines where 8.5 kb of the rat CYP1A1 promoter is cloned upstream of the lacZ reporter gene (1), we describe the expression of the CYP1A1-driven reporter gene in all tissues through-out… CONTINUE READING

From This Paper

Topics from this paper.
10 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…