The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation

@article{Laaksonen2014TheMS,
  title={The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation},
  author={Hannes Laaksonen and Andr{\'e} Ortlieb Guerreiro-Cacais and Milena Z. Adzemovic and Roham Parsa and Manuel Zeitelhofer and Maja Jagodic and Tomas Olsson},
  journal={Genes and Immunity},
  year={2014},
  volume={15},
  pages={457-465}
}
Single-nucleotide polymorphisms close to IL22RA2, coding for the soluble interleukin (IL)-22-binding protein (IL-22BP), are strongly and reproducibly associated with multiple sclerosis (MS), but there is little data on how this molecule may affect neuroinflammation. Here, we have studied the mouse ortholog in C57BL/6 wild-type and Il22ra2-deficient mice in the context of experimental autoimmune encephalomyelitis (myelin oligodendrocyte glycoprotein-EAE). In wild-type mice, we demonstrated… CONTINUE READING

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The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation .
The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation .
The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation .
The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation .
The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation .
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