The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells.

@article{Laugel2011TheMR,
  title={The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells.},
  author={Bruno F Laugel and David K Cole and Mathew Clement and Linda Wooldridge and David A. Price and Andrew K. Sewell},
  journal={Journal of leukocyte biology},
  year={2011},
  volume={90 6},
  pages={1089-99}
}
Short peptide fragments generated by intracellular protein cleavage are presented on the surface of most nucleated cells bound to highly polymorphic MHCI molecules. These pMHCI complexes constitute an interface that allows the immune system to identify and eradicate anomalous cells, such as those that harbor infectious agents, through the activation of CTLs. Molecular recognition of pMHCI complexes is mediated primarily by clonally distributed TCRs expressed on the surface of CTLs. The… CONTINUE READING