The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation.

@article{Buratti2010TheMR,
  title={The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation.},
  author={Emanuele Buratti and Francisco E. Baralle},
  journal={RNA biology},
  year={2010},
  volume={7 4},
  pages={420-9}
}
Heterogeneous ribonucleoproteins (hnRNPs) are multifunctional RNA-binding proteins (RBPs) involved in many cellular processes. They participate in most gene expression pathways, from DNA replication and repair to mRNA translation. Among this class of proteins, TDP-43 (and more recently FUS/TLS) have received considerable attention due to their involvement in several neurodegenerative diseases. This finding has prompted many research groups to focus on the gene expression pathways that are… CONTINUE READING
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