The multiple phenotypes of allosteric receptor mutants.

@article{Galzi1996TheMP,
  title={The multiple phenotypes of allosteric receptor mutants.},
  author={Jean Luc Galzi and Stuart J. Edelstein and Jean-Pierre Changeux},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 5},
  pages={
          1853-8
        }
}
Channel-linked neurotransmitter receptors are membrane-bound heterooligomers made up of distinct, although homologous, subunits. They mediate chemo-electrical signal transduction and its regulation via interconversion between multiple conformations that exhibit distinct pharmacological properties and biological activities. The large diversity of functional properties and the widely pleiotropic phenotypes, which arise from point mutations in their subunits (or from subunit substitutions), are… CONTINUE READING

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