The multiple orthogonal tools approach to define molecular causation in the validation of druggable targets.

@article{Hardy2004TheMO,
  title={The multiple orthogonal tools approach to define molecular causation in the validation of druggable targets.},
  author={Larry W. Hardy and Norton P Peet},
  journal={Drug discovery today},
  year={2004},
  volume={9 3},
  pages={117-26}
}
Many genetic (gene deletion, interruption or mutation), epigenetic (such as antisense or small interfering RNA) and immunological methods are being applied in 'high-throughput target validation' studies of the novel potential targets arising from whole genome sequencing. Such applications often focus on 'loss of function' approaches. However, target validation is most reliable when multiple orthogonal approaches are used. Initiating a target-based discovery project based on correlative evidence… CONTINUE READING

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